A single Excel worksheet holds 1,048,576 rows and 16,384 columns. [1] That limit is not the main problem with a
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Novo Nordisk’s Canadian semaglutide patent, CA 2601784, lapsed because a maintenance fee went unpaid in 2019. The fee was CAD
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Merck reports that the main US patent on Keytruda expires in 2028, and the same table shows 2031 for the
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Pfizer lost US exclusivity on Lipitor on November 30, 2011. [1] The EU compound patent for the same drug expired
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The Eliquis composition patent in the FDA Orange Book expires on November 21, 2026. [1] Bristol Myers Squibb and Pfizer
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Keytruda sold $31.68 billion in 2025. That was 48.7% of Merck’s total sales of $65.01 billion. [1] Merck lists the
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FDA listed 91 first generic drug approvals for 2025 [2]. Each one passed through a chain of checks that a
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The European Medicines Agency authorized Eliquis (apixaban) on 18 May 2011 [10]. The compound patent behind it, EP 1 427
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The main US combination patent for Entresto expired on July 15, 2025, with its pediatric exclusivity. [1] Novartis’s own 2023
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